Spirituality and Depression

I wonder sometimes if melancholic/depressed people simply have a enhanced spiritual sense of being separated from God? Let me be clear depression is a serious and real mental illness based on chemical imbalances in the brain. What I am trying to say is that I have observed people during my lifetime who tend to be more of a somber/blue mood most of the time. Often they are seekers of …what? The true self? God? Nirvana? Whatever it is they are seeking they have somehow this natural disposition to going on “the way.”

John Wesley wrote about spiritual senses, spiritual sensibility. Faith is sometimes defined as a belief that there is a mystery in reality. I guess I want to ask is it possible that we feel sad about our separation from the divine without knowing what we are feeling sad about?

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